IONIZING RADIATION-INDUCED EXTRACELLULAR VESICLE RELEASE PROMOTES AKT-ASSOCIATED SURVIVAL RESPONSE IN SH-SY5Y NEUROBLASTOMA CELLS

Ionizing Radiation-Induced Extracellular Vesicle Release Promotes AKT-Associated Survival Response in SH-SY5Y Neuroblastoma Cells

Radiation therapy is one of the most effective methods of tumor eradication; however, in some forms of neuroblastoma, radiation can increase the risk of secondary neoplasms, 14765-prb-a01 due to the ability of irradiated cells to transmit pro-survival signals to non-irradiated cells through vesicle secretion.The aims of this study were to character

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Synergistic Effect of Subtoxic-dose Cisplatin and TRAIL to Mediate Apoptosis by Down-regulating Decoy Receptor 2 and Up-regulating Caspase-8, Caspase-9 and Bax Expression on NCI-H460 and A549 Cells

Objective(s): Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (NSCLC) exhibit TRAIL-resistance.The purpose of this study was to determine whether subtoxic-dose cisplatin and TRAIL could synergistically enhance apop

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